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Chirosolve Screening (Duration: 3 to 5 days)
Target racemate is screened using 4 kits against 384 combinations of resolving agents/solvents. In some cases, we may customize the kits to include specific resolving agents or solvents if the racemate properties are known.
If the racemate is a weak base, strong acid kits are used. Glass Vial Kits" that only require 2 mmol of racemate (as opposed to 12 mmol racemate needed by standard kits) may be used if only a small amount of racemate is available.
Results are provided in terms of product yield and specific rotation values on a digital polarimeter. We also identify two or three of the highest purity-and-yield combinations for scale-up.
Note: All our services are considered “research projects” and we cannot guarantee that target enantiomeric purity will be achieved. Work is done on a best-effort basis.
Performance
Over the years, ChiroSolve has performed over 100 screening projects with 100% success rate
Sample racemate can have one or more chiral centers; and be of type acid, base, alcohol, aldehyde, ketone and amino acid.
Key Benefits
Confidence in selecting candidates for product development and strategies
Establish an IP foundation
Easy, rapid preparation of enantiomer for early lead optimization and preclinical testing