Comprehensive Screening Solution

ChiroSolve Screening Kits comprehensively identify effective chiral separation methods through diastereomeric crystallization of enantiomers. It delivers hundreds of unique combinations of resolving agents and solvents in calibrated amounts that maximize the preferential crystal formation of one enantiomer; while the other isomer stays in filtrate.

An experiment will employ either acid or base kits depending on the properties of the racemate; and can be finished within 24 hours (actual hands-on work: 1 hour). For a neutral racemate, pre-processing of the racemate is required to bring it to either acidic or basic moiety before using the ChiroSolve kits. Racemate requirements are 0.005 to 0.03 mmol per vial depending on the kit format. Kits can be categorized into:

Key features:

  • 4 kits per racemate, offering 384 combinations of resolving agents and solvents to screen against
  • Disposable standard high-throughput kits accommodate easy robotic manipulation
  • Heat and chemical-resistant kit material allows whole experiment to be done inside the kit
  • Kits have long shelf life (up to 10 years at room temperature)
  • Very little amount of racemate is needed (0.005 to 0.03 mmol per vial)

Key benefits:

  • Chiral separation method defined in matter of days
  • Works against any racemate (acid, base, alcohol, aldehyde, ketone, amino acid, racemate with multiple chiral centers)
  • Comprehensive screening ensures unbiased results
  • Early identification of most separation conditions establishes IP foundation
  • Reduced method development time and labor
  • Simple means of developing complete step-by-step procedure that includes iterative crystallization that attains target enantiomeric purity

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